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  • 11.0 [archived version]
STRINGSTRING
STX10 STX10 STX8 STX8 STX6 STX6 RABL2B RABL2B ULK3 ULK3 STK35 STK35 PDIK1L PDIK1L RAB11A RAB11A WIPF2 WIPF2 RAB25 RAB25 ULK1 ULK1 ULK2 ULK2 RAB11B RAB11B YIPF7 YIPF7 YIPF2 YIPF2 YIPF5 YIPF5 YIPF1 YIPF1 ATP6V0A4 ATP6V0A4 YIPF4 YIPF4 TCIRG1 TCIRG1 ATP6V0A1 ATP6V0A1 YIPF3 YIPF3 ATP6V0A2 ATP6V0A2 RABL2A RABL2A YIPF6 YIPF6 TVP23A TVP23A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
YIPF1Protein YIPF1; Yip1 domain family member 1; Belongs to the YIP1 family (306 aa)
YIPF4Protein YIPF4; Involved in the maintenance of the Golgi structure; Belongs to the YIP1 family (244 aa)
YIPF2Protein YIPF2; Yip1 domain family member 2 (316 aa)
STX6Syntaxin-6; Involved in intracellular vesicle trafficking; Syntaxins (255 aa)
RAB11ARas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. T [...] (216 aa)
ATP6V0A1V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity); V-type ATPases (838 aa)
TCIRG1V-type proton ATPase 116 kDa subunit a isoform 3; Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation; Belongs to the V-ATPase 116 kDa subunit family (830 aa)
YIPF5Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi; Yip1 domain containing (257 aa)
TVP23ATrans-golgi network vesicle protein 23 homolog A; Belongs to the TVP23 family (213 aa)
STX8Syntaxin-8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER; Belongs to the syntaxin family (236 aa)
ATP6V0A4V-type proton ATPase 116 kDa subunit a isoform 4; Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney; V-type ATPases (840 aa)
WIPF2WAS/WASL-interacting protein family member 2; Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system (440 aa)
ULK1Serine/threonine-protein kinase ULK1; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, lead [...] (1050 aa)
ATP6V0A2V-type proton ATPase 116 kDa subunit a isoform 2; Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation; Belongs to the V-ATPase 116 kDa subunit family (856 aa)
YIPF7Protein YIPF7; Yip1 domain family member 7; Belongs to the YIP1 family (280 aa)
RAB11BRas-related protein Rab-11B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epitheli [...] (218 aa)
RAB25Ras-related protein Rab-25; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity); Belongs to the small GTPase superfamily. Rab family (213 aa)
YIPF3Protein YIPF3; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis; Yip1 domain containing (350 aa)
PDIK1LSerine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family (341 aa)
STK35Serine/threonine kinase 35; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family (534 aa)
RABL2ARab-like protein 2A; Plays an essential role in male fertility, sperm intra- flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail; RAB like GTPases (228 aa)
ULK2Serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG [...] (1036 aa)
RABL2BRab-like protein 2B; RAB, member of RAS oncogene family like 2B (238 aa)
ULK3Serine/threonine-protein kinase ULK3; Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand- interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH- dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as we [...] (472 aa)
YIPF6Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression; Yip1 domain containing (236 aa)
STX10Syntaxin-10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family (249 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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