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STRINGSTRING
ZNF761 ZNF761 DDX24 DDX24 AKT1 AKT1 C17orf49 C17orf49 ZNF92 ZNF92 CCDC15 CCDC15 CHUK CHUK TAF1C TAF1C TAF1A TAF1A TRIM10 TRIM10 TBK1 TBK1 HINFP HINFP TAF1D TAF1D TAF1B TAF1B TRIM47 TRIM47 ZNF91 ZNF91 SPATS2L SPATS2L TRIM69 TRIM69 TRIM44 TRIM44 PBX3 PBX3 MORN4 MORN4 TRIM11 TRIM11 CCDC112 CCDC112 ANKRD30B ANKRD30B DACH2 DACH2 TRIM17 TRIM17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRIM47Tripartite motif containing 47; Ring finger proteins (638 aa)
TAF1BTATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3; Belongs to the RRN7/TAF1B family (588 aa)
TRIM11E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation [...] (468 aa)
TRIM44Tripartite motif-containing protein 44; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression; Ring finger proteins (344 aa)
ZNF91Zinc finger protein 91; Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons- recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1. May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo; Belongs to the krueppel C2H2-type zinc-finger protein family (1191 aa)
MORN4MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma (146 aa)
HINFPHistone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter; Zinc fingers C2H2-type (517 aa)
TBK1Serine/threonine-protein kinase TBK1; Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form s [...] (729 aa)
ZNF92Zinc finger protein 92; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (586 aa)
TAF1ATATA box-binding protein-associated factor RNA polymerase I subunit A; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre- initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (450 aa)
CCDC15Coiled-coil domain containing 15 (951 aa)
ANKRD30BAnkyrin repeat domain-containing protein 30B; Ankyrin repeat domain containing (1392 aa)
TRIM17E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase; Belongs to the TRIM/RBCC family (477 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into [...] (745 aa)
DACH2Dachshund homolog 2; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlyin [...] (599 aa)
PBX3Pre-B-cell leukemia transcription factor 3; Transcriptional activator that binds the sequence 5’- ATCAATCAA-3’; TALE class homeoboxes and pseudogenes (434 aa)
CCDC112Coiled-coil domain containing 112 (529 aa)
TRIM10Tripartite motif-containing protein 10; Seems to play an important role in erythropoiesis; Belongs to the TRIM/RBCC family (481 aa)
TAF1DTATA box-binding protein-associated factor RNA polymerase I subunit D; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (278 aa)
C17orf49Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing (192 aa)
AKT1RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of th [...] (480 aa)
TRIM69E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis; Ring finger proteins (500 aa)
TAF1CTATA box-binding protein-associated factor RNA polymerase I subunit C; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via [...] (869 aa)
ZNF761Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type (746 aa)
DDX24ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily (859 aa)
SPATS2LSPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family (588 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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