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| SEC61B | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum; Belongs to the SEC61-beta family (96 aa) | |||
| RPL8 | 60S ribosomal protein L8; Component of the large ribosomal subunit (257 aa) | |||
| DDX18 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily (670 aa) | |||
| RPL37 | 60S ribosomal protein L37; Binds to the 23S rRNA; L ribosomal proteins (97 aa) | |||
| NEMF | Nuclear export mediator factor NEMF; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex. May indirectly play a role in nuclear export (1076 aa) | |||
| RPL21 | 60S ribosomal protein L21; Component of the large ribosomal subunit (160 aa) | |||
| RPL22 | Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family (128 aa) | |||
| RPL12 | 60S ribosomal protein L12; Binds directly to 26S ribosomal RNA (165 aa) | |||
| RPL39 | Ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family (51 aa) | |||
| DKC1 | H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...] (514 aa) | |||
| EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] (333 aa) | |||
| NOP56 | Nucleolar protein 56; Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family (594 aa) | |||
| RPL34 | 60S ribosomal protein L34; Component of the large ribosomal subunit (117 aa) | |||
| RPL31 | Ribosomal protein L31 (128 aa) | |||
| UBA52 | Ubiquitin-60S ribosomal protein L40; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be invo [...] (128 aa) | |||
| RPL23A | 60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family (156 aa) | |||
| RPL9 | L ribosomal proteins (192 aa) | |||
| RPL32 | Ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family (135 aa) | |||
| RPL35A | 60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (110 aa) | |||
| RPL23 | Ribosomal protein L23 (140 aa) | |||
| RPL30 | Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family (115 aa) | |||
| RPL26L1 | Ribosomal protein L26 like 1; Belongs to the universal ribosomal protein uL24 family (145 aa) | |||
| RPL26 | Ribosomal protein L26 (145 aa) | |||
| RPL36 | 60S ribosomal protein L36; Component of the large ribosomal subunit (105 aa) | |||
| RPL27 | 60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (136 aa) | |||
| LTN1 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity); Armadillo-like helical domain containing (1812 aa) | |||
