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C22orf23 | UPF0193 protein EVG1; Chromosome 22 open reading frame 23 (217 aa) | |||
C1orf74 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family (269 aa) | |||
WWTR1 | WW domain-containing transcription regulator protein 1; Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances [...] (400 aa) |