| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DCC | DRAXIN | ENSP00000389140 | ENSP00000294485 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene; Fibronectin type III domain containing | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway; Belongs to the draxin family | 0.891 |
| DCC | NTN1 | ENSP00000389140 | ENSP00000173229 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene; Fibronectin type III domain containing | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.998 |
| DCC | NTN3 | ENSP00000389140 | ENSP00000293973 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene; Fibronectin type III domain containing | Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons | 0.479 |
| DCC | NTN5 | ENSP00000389140 | ENSP00000270235 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene; Fibronectin type III domain containing | Netrin-5; Netrin 5; Netrins | 0.554 |
| DCC | NTNG1 | ENSP00000389140 | ENSP00000359085 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene; Fibronectin type III domain containing | Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins | 0.498 |
| DCC | NTNG2 | ENSP00000389140 | ENSP00000376921 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene; Fibronectin type III domain containing | Netrin-G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins | 0.479 |
| DRAXIN | DCC | ENSP00000294485 | ENSP00000389140 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway; Belongs to the draxin family | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene; Fibronectin type III domain containing | 0.891 |
| DRAXIN | IGDCC3 | ENSP00000294485 | ENSP00000332773 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway; Belongs to the draxin family | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | 0.408 |
| DRAXIN | NEO1 | ENSP00000294485 | ENSP00000341198 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway; Belongs to the draxin family | Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response; Belongs to the immunoglobulin superfamily. DCC family | 0.786 |
| DRAXIN | NTN1 | ENSP00000294485 | ENSP00000173229 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway; Belongs to the draxin family | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.974 |
| DRAXIN | NTN3 | ENSP00000294485 | ENSP00000293973 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway; Belongs to the draxin family | Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons | 0.480 |
| DRAXIN | NTNG1 | ENSP00000294485 | ENSP00000359085 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway; Belongs to the draxin family | Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins | 0.457 |
| DRAXIN | PRTG | ENSP00000294485 | ENSP00000373937 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway; Belongs to the draxin family | Protogenin; May play a role in anteroposterior axis elongation; Fibronectin type III domain containing | 0.470 |
| IGDCC3 | DRAXIN | ENSP00000332773 | ENSP00000294485 | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway; Belongs to the draxin family | 0.408 |
| IGDCC3 | NTN1 | ENSP00000332773 | ENSP00000173229 | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.447 |
| IGDCC3 | NTN3 | ENSP00000332773 | ENSP00000293973 | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons | 0.432 |
| IGDCC3 | NTN5 | ENSP00000332773 | ENSP00000270235 | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | Netrin-5; Netrin 5; Netrins | 0.432 |
| IGDCC3 | NTNG1 | ENSP00000332773 | ENSP00000359085 | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins | 0.448 |
| IGDCC3 | NTNG2 | ENSP00000332773 | ENSP00000376921 | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | Netrin-G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins | 0.432 |
| IGDCC3 | SDK2 | ENSP00000332773 | ENSP00000376421 | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | 0.446 |
