26 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MIP	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family (263 aa)
	GOLGA6A	Golgin A6 family member A; Belongs to the GOLGA6 family (693 aa)
	ZFPL1	Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130 (310 aa)
	GOLGA6C	Golgin A6 family member C; Belongs to the GOLGA6 family (693 aa)
	OSBPL2	Oxysterol-binding protein-related protein 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Binds 25-hydroxycholesterol; Belongs to the OSBP family (480 aa)
	GOLGA8R	Golgin A8 family member R (631 aa)
	LAMP1	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules (417 aa)
	GOLGA8B	Golgin subfamily A member 8B; May be involved in maintaining Golgi structure; Belongs to the GOLGA8 family (603 aa)
	VAPA	Vesicle-associated membrane protein-associated protein A; VAMP associated protein A (294 aa)
	GOLGA8A	Golgin subfamily A member 8A; May be involved in maintaining Golgi structure (603 aa)
	ACBD5	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (525 aa)
	GOLGA6D	Golgin A6 family member D; Belongs to the GOLGA6 family (693 aa)
	GOLGA8N	Golgin A8 family member N; Belongs to the GOLGA8 family (632 aa)
	GOLGA6B	Golgin A6 family member B; Belongs to the GOLGA6 family (693 aa)
	GOLGA2	Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly- phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing teth [...] (1002 aa)
	GOLGA8O	Golgin A8 family member O; Belongs to the GOLGA6 family (632 aa)
	GOLGA8K	Golgin A8 family member K; Belongs to the GOLGA8 family (630 aa)
	GOLGA8F	Golgin A8 family member F; Belongs to the GOLGA8 family (648 aa)
	GOLGA6L2	Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family (909 aa)
	GOLGA8S	Golgin A8 family member S (625 aa)
	GOLGA8T	Golgin A8 family member T (631 aa)
	GOLGA8J	Golgin A8 family member J; Belongs to the GOLGA8 family (632 aa)
	GOLGA8H	Golgin A8 family member H; Belongs to the GOLGA8 family (632 aa)
	GOLGA8M	Golgin A8 family member M (632 aa)
	GOLGA8Q	Golgin A8 family member Q (632 aa)
	FKBP8	Peptidyl-prolyl cis-trans isomerase FKBP8; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis; FKBP prolyl isomerases (413 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACBD5	VAPA	ENSP00000379568	ENSP00000345656	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters	Vesicle-associated membrane protein-associated protein A; VAMP associated protein A	0.754
ACBD5	ZFPL1	ENSP00000379568	ENSP00000294258	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters	Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130	0.547
GOLGA2	LAMP1	ENSP00000416097	ENSP00000333298	Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly- phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing teth [...]	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	0.690
GOLGA2	ZFPL1	ENSP00000416097	ENSP00000294258	Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly- phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing teth [...]	Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130	0.584
GOLGA8A	GOLGA8B	ENSP00000352111	ENSP00000343064	Golgin subfamily A member 8A; May be involved in maintaining Golgi structure	Golgin subfamily A member 8B; May be involved in maintaining Golgi structure; Belongs to the GOLGA8 family	0.554
GOLGA8B	GOLGA8A	ENSP00000343064	ENSP00000352111	Golgin subfamily A member 8B; May be involved in maintaining Golgi structure; Belongs to the GOLGA8 family	Golgin subfamily A member 8A; May be involved in maintaining Golgi structure	0.554
LAMP1	GOLGA2	ENSP00000333298	ENSP00000416097	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly- phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing teth [...]	0.690
LAMP1	VAPA	ENSP00000333298	ENSP00000345656	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	Vesicle-associated membrane protein-associated protein A; VAMP associated protein A	0.935
LAMP1	ZFPL1	ENSP00000333298	ENSP00000294258	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130	0.422
OSBPL2	VAPA	ENSP00000316649	ENSP00000345656	Oxysterol-binding protein-related protein 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Binds 25-hydroxycholesterol; Belongs to the OSBP family	Vesicle-associated membrane protein-associated protein A; VAMP associated protein A	0.813
OSBPL2	ZFPL1	ENSP00000316649	ENSP00000294258	Oxysterol-binding protein-related protein 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Binds 25-hydroxycholesterol; Belongs to the OSBP family	Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130	0.547
VAPA	ACBD5	ENSP00000345656	ENSP00000379568	Vesicle-associated membrane protein-associated protein A; VAMP associated protein A	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters	0.754
VAPA	LAMP1	ENSP00000345656	ENSP00000333298	Vesicle-associated membrane protein-associated protein A; VAMP associated protein A	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	0.935
VAPA	OSBPL2	ENSP00000345656	ENSP00000316649	Vesicle-associated membrane protein-associated protein A; VAMP associated protein A	Oxysterol-binding protein-related protein 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Binds 25-hydroxycholesterol; Belongs to the OSBP family	0.813
ZFPL1	ACBD5	ENSP00000294258	ENSP00000379568	Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters	0.547
ZFPL1	GOLGA2	ENSP00000294258	ENSP00000416097	Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130	Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly- phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing teth [...]	0.584
ZFPL1	LAMP1	ENSP00000294258	ENSP00000333298	Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	0.422
ZFPL1	OSBPL2	ENSP00000294258	ENSP00000316649	Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130	Oxysterol-binding protein-related protein 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Binds 25-hydroxycholesterol; Belongs to the OSBP family	0.547

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2020

Credits

Access

Info

About