10 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	KHK	Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate; Belongs to the carbohydrate kinase PfkB family (298 aa)
	SORD	Sorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm; Belongs to the zinc-containing alcohol dehydrogenase family (357 aa)
	FUK	L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides (1084 aa)
	HK2	Hexokinase-2; Hexokinase 2; Belongs to the hexokinase family (917 aa)
	HK3	Hexokinase-3; Hexokinase 3 (923 aa)
	KLK5	Kallikrein-5; May be involved in desquamation; Belongs to the peptidase S1 family. Kallikrein subfamily (293 aa)
	HKDC1	Putative hexokinase HKDC1; Hexokinase domain containing 1 (917 aa)
	FPGT	Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids (607 aa)
	HK1	Hexokinase-1; Hexokinase 1 (921 aa)
	PRKCSH	Glucosidase 2 subunit beta; Regulatory subunit of glucosidase II; EF-hand domain containing (535 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FPGT	FUK	ENSP00000359935	ENSP00000288078	Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids	L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides	0.941
FUK	FPGT	ENSP00000288078	ENSP00000359935	L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides	Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids	0.941
FUK	HK1	ENSP00000288078	ENSP00000402103	L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides	Hexokinase-1; Hexokinase 1	0.818
FUK	HK2	ENSP00000288078	ENSP00000290573	L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides	Hexokinase-2; Hexokinase 2; Belongs to the hexokinase family	0.818
FUK	HK3	ENSP00000288078	ENSP00000292432	L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides	Hexokinase-3; Hexokinase 3	0.815
FUK	HKDC1	ENSP00000288078	ENSP00000346643	L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides	Putative hexokinase HKDC1; Hexokinase domain containing 1	0.827
FUK	KHK	ENSP00000288078	ENSP00000260599	L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides	Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate; Belongs to the carbohydrate kinase PfkB family	0.800
FUK	SORD	ENSP00000288078	ENSP00000267814	L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides	Sorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm; Belongs to the zinc-containing alcohol dehydrogenase family	0.808
HK1	FUK	ENSP00000402103	ENSP00000288078	Hexokinase-1; Hexokinase 1	L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides	0.818
HK1	HK2	ENSP00000402103	ENSP00000290573	Hexokinase-1; Hexokinase 1	Hexokinase-2; Hexokinase 2; Belongs to the hexokinase family	0.986
HK1	HK3	ENSP00000402103	ENSP00000292432	Hexokinase-1; Hexokinase 1	Hexokinase-3; Hexokinase 3	0.974
HK1	HKDC1	ENSP00000402103	ENSP00000346643	Hexokinase-1; Hexokinase 1	Putative hexokinase HKDC1; Hexokinase domain containing 1	0.986
HK1	KHK	ENSP00000402103	ENSP00000260599	Hexokinase-1; Hexokinase 1	Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate; Belongs to the carbohydrate kinase PfkB family	0.971
HK1	SORD	ENSP00000402103	ENSP00000267814	Hexokinase-1; Hexokinase 1	Sorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm; Belongs to the zinc-containing alcohol dehydrogenase family	0.956
HK2	FUK	ENSP00000290573	ENSP00000288078	Hexokinase-2; Hexokinase 2; Belongs to the hexokinase family	L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides	0.818
HK2	HK1	ENSP00000290573	ENSP00000402103	Hexokinase-2; Hexokinase 2; Belongs to the hexokinase family	Hexokinase-1; Hexokinase 1	0.986
HK2	HK3	ENSP00000290573	ENSP00000292432	Hexokinase-2; Hexokinase 2; Belongs to the hexokinase family	Hexokinase-3; Hexokinase 3	0.967
HK2	HKDC1	ENSP00000290573	ENSP00000346643	Hexokinase-2; Hexokinase 2; Belongs to the hexokinase family	Putative hexokinase HKDC1; Hexokinase domain containing 1	0.804
HK2	KHK	ENSP00000290573	ENSP00000260599	Hexokinase-2; Hexokinase 2; Belongs to the hexokinase family	Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate; Belongs to the carbohydrate kinase PfkB family	0.928
HK2	SORD	ENSP00000290573	ENSP00000267814	Hexokinase-2; Hexokinase 2; Belongs to the hexokinase family	Sorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm; Belongs to the zinc-containing alcohol dehydrogenase family	0.922

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