5 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CAPNS1	Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing (268 aa)
	C8orf37	Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated (207 aa)
	CST6	Cystatin-M; Shows moderate inhibition of cathepsin B but is not active against cathepsin C; Belongs to the cystatin family (149 aa)
	FAM111B	Protein FAM111B; Family with sequence similarity 111 member B; Belongs to the FAM111 family (734 aa)
	XPNPEP3	X-prolyl aminopeptidase 3; Belongs to the peptidase M24B family (507 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAPNS1	FAM111B	ENSP00000246533	ENSP00000341565	Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing	Protein FAM111B; Family with sequence similarity 111 member B; Belongs to the FAM111 family	0.680
FAM111B	CAPNS1	ENSP00000341565	ENSP00000246533	Protein FAM111B; Family with sequence similarity 111 member B; Belongs to the FAM111 family	Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing	0.680

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