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| ESF1 | ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) (851 aa) | |||
| CSNK2A1 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] (391 aa) | |||
| FBL | rRNA 2’-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2’-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of ’Gln-105’ of histone H2A (H2AQ104me), a modification [...] (321 aa) | |||
| UTP18 | U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA; UTPb subcomplex (556 aa) | |||
| KRR1 | KRR1 small subunit processome component homolog; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity) (381 aa) | |||
| BYSL | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family (437 aa) | |||
| RRP36 | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA; Belongs to the RRP36 family (259 aa) | |||
| DDX49 | Probable ATP-dependent RNA helicase DDX49; DEAD-box helicase 49; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily (483 aa) | |||
| UTP6 | U3 small nucleolar RNA-associated protein 6 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA; UTPb subcomplex (597 aa) | |||
| CSNK2A2 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] (350 aa) | |||
| DDX18 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily (670 aa) | |||
| PNO1 | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA (252 aa) | |||
| ABT1 | Activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity); Belongs to the ESF2/ABP1 family (272 aa) | |||
| NOM1 | Nucleolar MIF4G domain-containing protein 1; Plays a role in targeting PPP1CA to the nucleolus; Protein phosphatase 1 regulatory subunits (860 aa) | |||
| DHX32 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; DEAH-box helicase 32; Belongs to the DEAD box helicase family. DEAH subfamily (743 aa) | |||
| KCTD19 | BTB/POZ domain-containing protein KCTD19; Potassium channel tetramerization domain containing 19 (926 aa) | |||
| WDR3 | WD repeat-containing protein 3; WD repeat domain containing; Belongs to the WD repeat WDR3/UTP12 family (943 aa) | |||
| DDX10 | Probable ATP-dependent RNA helicase DDX10; Putative ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily (875 aa) | |||
| DHX15 | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily (795 aa) | |||
| TBP | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase [...] (339 aa) | |||
| DQX1 | ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1 (717 aa) | |||
| FTSJ3 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily (847 aa) | |||
| NOP14 | Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity); Belongs to the NOP14 family (857 aa) | |||
| DIEXF | Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs (756 aa) | |||
| RNF151 | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins (245 aa) | |||
| CSNK2A3 | Casein kinase II subunit alpha 3; Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down- regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression (391 aa) | |||
