• Version:
  • 11.0 [archived version]
STRINGSTRING
MYH3 MYH3 ZNF679 ZNF679 MCMDC2 MCMDC2 FCGR3A FCGR3A CA3 CA3 DNAJC11 DNAJC11 DPYD DPYD COX6A1 COX6A1 ZKSCAN4 ZKSCAN4 IGSF11 IGSF11 CPA4 CPA4 LXN LXN GSG1L GSG1L SPAG7 SPAG7 YIF1B YIF1B TMEM14A TMEM14A PPP1R3C PPP1R3C ZNF430 ZNF430 SHKBP1 SHKBP1 SH3BGRL SH3BGRL BOC BOC MAGEA8 MAGEA8 ZCCHC17 ZCCHC17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPAG7Sperm associated antigen 7 (227 aa)
TMEM14ATransmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family (99 aa)
CPA4Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family (421 aa)
COX6A1Cytochrome c oxidase subunit 6A1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (109 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types; Protein phosphatase 1 regulatory subunits (317 aa)
ZNF430Zinc finger protein 430; May be involved in transcriptional regulation; Zinc fingers C2H2-type (570 aa)
LXNLatexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation; Belongs to the protease inhibitor I47 (latexin) family (222 aa)
CA3Carbonic anhydrase 3; Reversible hydration of carbon dioxide; Carbonic anhydrases (260 aa)
SHKBP1SH3KBP1-binding protein 1; Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation; Belongs to the KCTD3 family (707 aa)
YIF1BProtein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family (314 aa)
FCGR3ALow affinity immunoglobulin gamma Fc region receptor III-A; Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis; CD molecules (290 aa)
DPYDDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil; Belongs to the dihydropyrimidine dehydrogenase family (1025 aa)
SH3BGRLSH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like (114 aa)
ZKSCAN4Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family (545 aa)
DNAJC11DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family (559 aa)
IGSF11Immunoglobulin superfamily member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth; I-set domain containing (431 aa)
GSG1LGerm cell-specific gene 1-like protein; As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating (331 aa)
MCMDC2Minichromosome maintenance domain-containing protein 2; Plays an important role in meiotic recombination and associated DNA double-strand break repair; MCM family (681 aa)
ZNF679Zinc finger protein 679; May be involved in transcriptional regulation; Zinc fingers C2H2-type (411 aa)
BOCBrother of CDO; Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells; Fibronectin type III domain containing (1114 aa)
MAGEA8Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family (318 aa)
MYH3Myosin-3; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1940 aa)
ZCCHC17Nucleolar protein of 40 kDa; Zinc finger CCHC-type containing 17 (263 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]