• Version:
  • 11.0 [archived version]
STRINGSTRING
ITGB8 ITGB8 NXPH3 NXPH3 LMF1 LMF1 SERPINB11 SERPINB11 LMF2 LMF2 PNLIP PNLIP LIPC LIPC LPL LPL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB8Integrin beta-8; Integrin alpha-V/beta-8 is a receptor for fibronectin (769 aa)
LMF1Lipase maturation factor 1; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL (567 aa)
LIPCHepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (499 aa)
LPLLipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family (475 aa)
NXPH3Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family (252 aa)
PNLIPPancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family (465 aa)
LMF2Lipase maturation factor 2; Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity) (707 aa)
SERPINB11Serpin B11; Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change; Serpin peptidase inhibitors (392 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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