10 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

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Your Input:
	CLPS	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase (112 aa)
	PLA1A	Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production; Belongs to the AB hydrolase superfamily. Lipase family (456 aa)
	LIPH	Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG); Belongs to the AB hydrolase superfamily. Lipase family (451 aa)
	LIPC	Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (499 aa)
	LIPI	Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG); Belongs to the AB hydrolase superfamily. Lipase family (481 aa)
	PNLIP	Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family (465 aa)
	PNLIPRP3	Pancreatic lipase related protein 3; Lipases (467 aa)
	GLP1R	Glucagon-like peptide 1 receptor; G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity) (463 aa)
	LIPF	Lipase F, gastric type; Lipases (408 aa)
	PNLIPRP1	Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity); Belongs to the AB hydrolase superfamily. Lipase family (467 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLPS	LIPF	ENSP00000259938	ENSP00000377900	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase	Lipase F, gastric type; Lipases	0.558
CLPS	PNLIP	ENSP00000259938	ENSP00000358223	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase	Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family	0.997
CLPS	PNLIPRP1	ENSP00000259938	ENSP00000433933	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase	Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity); Belongs to the AB hydrolase superfamily. Lipase family	0.897
CLPS	PNLIPRP3	ENSP00000259938	ENSP00000358232	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase	Pancreatic lipase related protein 3; Lipases	0.720
LIPC	LIPF	ENSP00000299022	ENSP00000377900	Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin	Lipase F, gastric type; Lipases	0.918
LIPC	PNLIP	ENSP00000299022	ENSP00000358223	Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin	Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family	0.829
LIPC	PNLIPRP1	ENSP00000299022	ENSP00000433933	Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin	Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity); Belongs to the AB hydrolase superfamily. Lipase family	0.820
LIPC	PNLIPRP3	ENSP00000299022	ENSP00000358232	Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin	Pancreatic lipase related protein 3; Lipases	0.819
LIPF	CLPS	ENSP00000377900	ENSP00000259938	Lipase F, gastric type; Lipases	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase	0.558
LIPF	LIPC	ENSP00000377900	ENSP00000299022	Lipase F, gastric type; Lipases	Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin	0.918
LIPF	LIPH	ENSP00000377900	ENSP00000296252	Lipase F, gastric type; Lipases	Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG); Belongs to the AB hydrolase superfamily. Lipase family	0.410
LIPF	PNLIP	ENSP00000377900	ENSP00000358223	Lipase F, gastric type; Lipases	Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family	0.946
LIPF	PNLIPRP1	ENSP00000377900	ENSP00000433933	Lipase F, gastric type; Lipases	Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity); Belongs to the AB hydrolase superfamily. Lipase family	0.870
LIPF	PNLIPRP3	ENSP00000377900	ENSP00000358232	Lipase F, gastric type; Lipases	Pancreatic lipase related protein 3; Lipases	0.868
LIPH	LIPF	ENSP00000296252	ENSP00000377900	Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG); Belongs to the AB hydrolase superfamily. Lipase family	Lipase F, gastric type; Lipases	0.410
PNLIP	CLPS	ENSP00000358223	ENSP00000259938	Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family	Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase	0.997
PNLIP	LIPC	ENSP00000358223	ENSP00000299022	Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family	Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin	0.829
PNLIP	LIPF	ENSP00000358223	ENSP00000377900	Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family	Lipase F, gastric type; Lipases	0.946
PNLIP	PNLIPRP1	ENSP00000358223	ENSP00000433933	Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family	Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity); Belongs to the AB hydrolase superfamily. Lipase family	0.832
PNLIP	PNLIPRP3	ENSP00000358223	ENSP00000358232	Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family	Pancreatic lipase related protein 3; Lipases	0.800

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