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  • 11.0 [archived version]
STRINGSTRING
GOSR2 GOSR2 EBP EBP VPS13C VPS13C TMEM14A TMEM14A CERS2 CERS2 POMK POMK CYSTM1 CYSTM1 YIPF5 YIPF5 YIPF6 YIPF6 FAM3C FAM3C YIPF7 YIPF7 YIF1A YIF1A TMEM167A TMEM167A KCNA1 KCNA1 YIF1B YIF1B IER3IP1 IER3IP1 ADCY9 ADCY9 GNG5 GNG5 CCDC53 CCDC53 YIPF4 YIPF4 TMEM258 TMEM258 PTPRG PTPRG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM14ATransmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family (99 aa)
GOSR2Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network; Belongs to the GOSR2 family (213 aa)
YIPF4Protein YIPF4; Involved in the maintenance of the Golgi structure; Belongs to the YIP1 family (244 aa)
CCDC53WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting; Belongs to the CCDC53 family (194 aa)
IER3IP1Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity) (82 aa)
VPS13CVacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (3753 aa)
CYSTM1Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1 (97 aa)
CERS2Ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis; CERS class homeoboxes (380 aa)
YIPF5Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi; Yip1 domain containing (257 aa)
ADCY9Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors; Adenylate cyclases (1353 aa)
POMKProtein O-mannose kinase; Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N- acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only [...] (350 aa)
YIPF7Protein YIPF7; Yip1 domain family member 7; Belongs to the YIP1 family (280 aa)
YIF1BProtein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family (314 aa)
FAM3CProtein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition (227 aa)
GNG5Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (68 aa)
YIF1AProtein YIF1A; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the YIF1 family (293 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference acro [...] (495 aa)
EBP3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family (230 aa)
YIPF6Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression; Yip1 domain containing (236 aa)
PTPRGReceptor-type tyrosine-protein phosphatase gamma; Possesses tyrosine phosphatase activity; Fibronectin type III domain containing (1445 aa)
TMEM167AProtein kish-A; Involved in the early part of the secretory pathway (72 aa)
TMEM258Transmembrane protein 258; Acts as component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for full OST catalytic activity in N-glycosylation. Involved in endoplasmic reticulum (ER) homeostasis in the colonic epithelium (By similarity); Belongs to the TMEM258 family (79 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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