26 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	KRT33A	Keratin, type I cuticular Ha3-I; Keratins, type I; Belongs to the intermediate filament family (404 aa)
	KRT23	Keratin, type I cytoskeletal 23; Keratins, type I (422 aa)
	KRT5	Keratin, type II cytoskeletal 5; Keratins, type II (590 aa)
	KRT1	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II (644 aa)
	KRT75	Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (551 aa)
	KRT6C	Keratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family (564 aa)
	KRT6B	Keratin, type II cytoskeletal 6B; Keratins, type II; Belongs to the intermediate filament family (564 aa)
	KRT85	Keratin, type II cuticular Hb5; Keratins, type II (507 aa)
	KRT84	Keratin, type II cuticular Hb4; Keratins, type II (600 aa)
	KRT82	Keratin, type II cuticular Hb2; Keratins, type II (513 aa)
	KRT71	Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (523 aa)
	KRT10	Keratin, type I cytoskeletal 10; Keratins, type I (584 aa)
	KRT83	Keratin, type II cuticular Hb3; Keratins, type II (493 aa)
	KRT72	Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) (511 aa)
	KRT78	Keratin, type II cytoskeletal 78; Keratins, type II (520 aa)
	KRT73	Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) (540 aa)
	KRT74	Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable); Keratins, type II (529 aa)
	PRSS1	Trypsin-1; Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates; Belongs to the peptidase S1 family (247 aa)
	KRT2	Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization; Keratins, type II (639 aa)
	KRT79	Keratin, type II cytoskeletal 79; Keratins, type II; Belongs to the intermediate filament family (535 aa)
	KRT7	Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7); Keratins, type II (469 aa)
	KRT76	Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification; Keratins, type II (638 aa)
	KRT77	Keratin, type II cytoskeletal 1b; Keratins, type II; Belongs to the intermediate filament family (578 aa)
	KRT40	Keratin, type I cytoskeletal 40; May play a role in late hair differentiation; Belongs to the intermediate filament family (431 aa)
	KRT6A	Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair; Belongs to the intermediate filament family (564 aa)
	KRT81	Keratin, type II cuticular Hb1; Keratins, type II (505 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRT1	KRT10	ENSP00000252244	ENSP00000269576	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 10; Keratins, type I	0.999
KRT1	KRT2	ENSP00000252244	ENSP00000310861	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization; Keratins, type II	0.996
KRT1	KRT23	ENSP00000252244	ENSP00000209718	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 23; Keratins, type I	0.911
KRT1	KRT33A	ENSP00000252244	ENSP00000007735	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha3-I; Keratins, type I; Belongs to the intermediate filament family	0.908
KRT1	KRT40	ENSP00000252244	ENSP00000366984	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 40; May play a role in late hair differentiation; Belongs to the intermediate filament family	0.906
KRT1	KRT5	ENSP00000252244	ENSP00000252242	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 5; Keratins, type II	0.997
KRT1	KRT6A	ENSP00000252244	ENSP00000369317	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair; Belongs to the intermediate filament family	0.911
KRT1	KRT6B	ENSP00000252244	ENSP00000252252	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 6B; Keratins, type II; Belongs to the intermediate filament family	0.911
KRT1	KRT6C	ENSP00000252244	ENSP00000252250	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family	0.913
KRT1	KRT7	ENSP00000252244	ENSP00000329243	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7); Keratins, type II	0.909
KRT1	KRT71	ENSP00000252244	ENSP00000267119	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle	0.901
KRT1	KRT72	ENSP00000252244	ENSP00000293745	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable)	0.908
KRT1	KRT73	ENSP00000252244	ENSP00000307014	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable)	0.911
KRT1	KRT74	ENSP00000252244	ENSP00000307240	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable); Keratins, type II	0.903
KRT1	KRT75	ENSP00000252244	ENSP00000252245	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle	0.901
KRT1	KRT76	ENSP00000252244	ENSP00000330101	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification; Keratins, type II	0.907
KRT1	KRT77	ENSP00000252244	ENSP00000342710	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 1b; Keratins, type II; Belongs to the intermediate filament family	0.995
KRT1	KRT78	ENSP00000252244	ENSP00000306261	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 78; Keratins, type II	0.905
KRT1	KRT79	ENSP00000252244	ENSP00000328358	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 79; Keratins, type II; Belongs to the intermediate filament family	0.903
KRT1	KRT81	ENSP00000252244	ENSP00000369349	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cuticular Hb1; Keratins, type II	0.901

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