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  • 11.0 [archived version]
STRINGSTRING
PLEKHJ1 PLEKHJ1 DCTN2 DCTN2 KRT6C KRT6C ABI2 ABI2 NUP54 NUP54 KRT78 KRT78 KRT71 KRT71 KRT2 KRT2 KRT4 KRT4 KRT86 KRT86 KRT72 KRT72 KRT83 KRT83 KRT1 KRT1 KRT33B KRT33B KRT81 KRT81 KRT79 KRT79 KRT82 KRT82 KRT85 KRT85 KRT80 KRT80 KRT8 KRT8 EPS15 EPS15 GRB2 GRB2 KRT6B KRT6B KRT3 KRT3 ATG2A ATG2A NEURL4 NEURL4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRT33BKeratin, type I cuticular Ha3-II; Keratins, type I; Belongs to the intermediate filament family (404 aa)
KRT1Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II (644 aa)
KRT6CKeratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family (564 aa)
KRT6BKeratin, type II cytoskeletal 6B; Keratins, type II; Belongs to the intermediate filament family (564 aa)
KRT85Keratin, type II cuticular Hb5; Keratins, type II (507 aa)
KRT82Keratin, type II cuticular Hb2; Keratins, type II (513 aa)
NUP54Nucleoporin p54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane; Nucleoporins (507 aa)
KRT71Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (523 aa)
KRT83Keratin, type II cuticular Hb3; Keratins, type II (493 aa)
KRT72Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) (511 aa)
ABI2Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity) (513 aa)
KRT78Keratin, type II cytoskeletal 78; Keratins, type II (520 aa)
KRT2Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization; Keratins, type II (639 aa)
KRT79Keratin, type II cytoskeletal 79; Keratins, type II; Belongs to the intermediate filament family (535 aa)
EPS15Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internali [...] (896 aa)
ATG2AAutophagy-related protein 2 homolog A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion; Belongs to the ATG2 family (1938 aa)
KRT81Keratin, type II cuticular Hb1; Keratins, type II (505 aa)
GRB2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing (217 aa)
KRT80Keratin, type II cytoskeletal 80; Keratins, type II (452 aa)
NEURL4Neuralized-like protein 4; Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers (1562 aa)
DCTN2Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin (406 aa)
KRT3Keratin, type II cytoskeletal 3; Keratins, type II (628 aa)
KRT86Keratin, type II cuticular Hb6; Keratins, type II (486 aa)
KRT4Keratin, type II cytoskeletal 4; Keratins, type II; Belongs to the intermediate filament family (520 aa)
KRT8Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Keratins, type II (511 aa)
PLEKHJ1Pleckstrin homology domain containing J1 (277 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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