• Version:
  • 11.0 [archived version]
STRINGSTRING
RNF113A RNF113A ZNF662 ZNF662 ZNF408 ZNF408 CTCF CTCF ZNF565 ZNF565 IBSP IBSP SP7 SP7 CCDC170 CCDC170 RNF113B RNF113B ZBTB40 ZBTB40 MIS18A MIS18A CCNH CCNH ZBTB2 ZBTB2 ZFP91 ZFP91 RBM17 RBM17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IBSPBone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment; SIBLING family (317 aa)
CCDC170Coiled-coil domain containing 170 (715 aa)
CCNHCyclin-H; Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout [...] (323 aa)
CTCFTranscriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by ac [...] (727 aa)
RNF113BRing finger protein 113B (322 aa)
MIS18AProtein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis (233 aa)
ZNF565Zinc finger protein 565; May be involved in transcriptional regulation; Zinc fingers C2H2-type (499 aa)
ZNF408Zinc finger protein 408; May be involved in transcriptional regulation; PR/SET domain family (720 aa)
ZBTB2Zinc finger and BTB domain-containing protein 2; May be involved in transcriptional regulation; BTB domain containing (514 aa)
ZNF662Zinc finger protein 662; Zinc fingers C2H2-type (452 aa)
ZFP91E3 ubiquitin-protein ligase ZFP91; Atypical E3 ubiquitin-protein ligase that mediates ’Lys- 63’-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family (570 aa)
RNF113ARING finger protein 113A; Spliceosomal Bact complex; Ring finger proteins (343 aa)
ZBTB40Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation; BTB domain containing (1239 aa)
RBM17Splicing factor 45; Splice factor that binds to the single-stranded 3’AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia; G-patch domain containing (401 aa)
SP7Transcription factor Sp7; Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity) (431 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]