| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DNAAF1 | ZMYND10 | ENSP00000367815 | ENSP00000231749 | Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | 0.846 |
| DNAL1 | RSU1 | ENSP00000452037 | ENSP00000367154 | Dynein light chain 1, axonemal; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-rig [...] | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro | 0.537 |
| DNAL1 | ZMYND10 | ENSP00000452037 | ENSP00000231749 | Dynein light chain 1, axonemal; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-rig [...] | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | 0.538 |
| LRRC46 | LRRC56 | ENSP00000269025 | ENSP00000270115 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | 0.611 |
| LRRC48 | LRRC56 | ENSP00000382140 | ENSP00000270115 | Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | 0.562 |
| LRRC56 | LRRC46 | ENSP00000270115 | ENSP00000269025 | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.611 |
| LRRC56 | LRRC48 | ENSP00000270115 | ENSP00000382140 | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility | 0.562 |
| LRRC56 | ZMYND10 | ENSP00000270115 | ENSP00000231749 | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | 0.443 |
| LRRC6 | ZMYND10 | ENSP00000484634 | ENSP00000231749 | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | 0.911 |
| PPP1R7 | RSU1 | ENSP00000234038 | ENSP00000367154 | Protein phosphatase 1 regulatory subunit 7; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro | 0.466 |
| RSU1 | DNAL1 | ENSP00000367154 | ENSP00000452037 | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro | Dynein light chain 1, axonemal; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-rig [...] | 0.537 |
| RSU1 | PPP1R7 | ENSP00000367154 | ENSP00000234038 | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro | Protein phosphatase 1 regulatory subunit 7; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family | 0.466 |
| RSU1 | ZMYND10 | ENSP00000367154 | ENSP00000231749 | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | 0.406 |
| RUNX1T1 | ZMYND10 | ENSP00000402257 | ENSP00000231749 | Protein CBFA2T1; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal; Zinc fingers MYND-type | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | 0.716 |
| ZMYND10 | DNAAF1 | ENSP00000231749 | ENSP00000367815 | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli | 0.846 |
| ZMYND10 | DNAL1 | ENSP00000231749 | ENSP00000452037 | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | Dynein light chain 1, axonemal; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-rig [...] | 0.538 |
| ZMYND10 | LRRC56 | ENSP00000231749 | ENSP00000270115 | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 | 0.443 |
| ZMYND10 | LRRC6 | ENSP00000231749 | ENSP00000484634 | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility | 0.911 |
| ZMYND10 | RSU1 | ENSP00000231749 | ENSP00000367154 | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro | 0.406 |
| ZMYND10 | RUNX1T1 | ENSP00000231749 | ENSP00000402257 | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family | Protein CBFA2T1; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal; Zinc fingers MYND-type | 0.716 |
