• Version:
  • 11.0 [archived version]
STRINGSTRING
GNB2L1 GNB2L1 WDR31 WDR31 RPS27A RPS27A RPS29 RPS29 RPS27L RPS27L RPL26L1 RPL26L1 ENSG00000260342 ENSG00000260342 RPS27 RPS27 RPL27A RPL27A RPS12 RPS12 RPS15 RPS15 RPL19 RPL19 RPS15A RPS15A UBA52 UBA52 RPS14 RPS14 RPS9 RPS9 RPL37A RPL37A RPL26 RPL26 RPS25 RPS25 STOM STOM RPL23 RPL23 RPS23 RPS23 ASIC2 ASIC2 ASIC1 ASIC1 ASIC3 ASIC3 PICK1 PICK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPL19Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family (196 aa)
ASIC2Acid sensing ion channel subunit 2 (563 aa)
ASIC1Acid-sensing ion channel 1; Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry [...] (574 aa)
RPS12Ribosomal protein S12 (132 aa)
RPS27AUbiquitin-40S ribosomal protein S27a; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be inv [...] (156 aa)
STOMErythrocyte band 7 integral membrane protein; Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity; Belongs to the band 7/mec-2 family (288 aa)
RPS2340S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
ASIC3Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties (549 aa)
RPS9Ribosomal protein S9 (194 aa)
RPS15ARibosomal protein S15a; Belongs to the universal ribosomal protein uS8 family (130 aa)
RPS27LRibosomal protein S27 like; Belongs to the eukaryotic ribosomal protein eS27 family (84 aa)
RPL27ARibosomal protein L27a; Belongs to the universal ribosomal protein uL15 family (148 aa)
RPS2740S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs; Belongs to the eukaryotic ribosomal protein eS27 family (84 aa)
WDR31WD repeat-containing protein 31; WD repeat domain containing (367 aa)
RPS29Ribosomal protein S29 (67 aa)
PICK1PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...] (415 aa)
RPS14Ribosomal protein S14 (151 aa)
UBA52Ubiquitin-60S ribosomal protein L40; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be invo [...] (128 aa)
RPL37ARibosomal protein L37a (92 aa)
RPL23Ribosomal protein L23 (140 aa)
GNB2L1Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily (317 aa)
RPL26L1Ribosomal protein L26 like 1; Belongs to the universal ribosomal protein uL24 family (145 aa)
RPS25Ribosomal protein S25 (125 aa)
ENSG00000260342Uncharacterized protein (237 aa)
RPL26Ribosomal protein L26 (145 aa)
RPS15Ribosomal protein S15 (145 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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