26 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	KRT33A	Keratin, type I cuticular Ha3-I; Keratins, type I; Belongs to the intermediate filament family (404 aa)
	KRT14	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro (472 aa)
	KRT20	Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity); Keratins, type I (424 aa)
	KRT23	Keratin, type I cytoskeletal 23; Keratins, type I (422 aa)
	KRT37	Keratin, type I cuticular Ha7; Keratins, type I; Belongs to the intermediate filament family (449 aa)
	KRT32	Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family (448 aa)
	KRT13	Keratin, type I cytoskeletal 13; Keratins, type I (458 aa)
	KRT38	Keratin, type I cuticular Ha8; Keratins, type I; Belongs to the intermediate filament family (456 aa)
	KRT9	Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly; Belongs to the intermediate filament family (623 aa)
	KRT12	Keratin, type I cytoskeletal 12; May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity); Keratins, type I (494 aa)
	KRT31	Keratin, type I cuticular Ha1; Keratins, type I (416 aa)
	KRT33B	Keratin, type I cuticular Ha3-II; Keratins, type I; Belongs to the intermediate filament family (404 aa)
	KRT5	Keratin, type II cytoskeletal 5; Keratins, type II (590 aa)
	KRT1	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II (644 aa)
	KRT75	Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (551 aa)
	KRT6C	Keratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family (564 aa)
	KRT6B	Keratin, type II cytoskeletal 6B; Keratins, type II; Belongs to the intermediate filament family (564 aa)
	KRT15	Keratin, type I cytoskeletal 15; Keratins, type I (456 aa)
	KRT85	Keratin, type II cuticular Hb5; Keratins, type II (507 aa)
	KRT84	Keratin, type II cuticular Hb4; Keratins, type II (600 aa)
	KRT82	Keratin, type II cuticular Hb2; Keratins, type II (513 aa)
	KRT24	Keratin, type I cytoskeletal 24; Keratins, type I (525 aa)
	KRT71	Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (523 aa)
	KRT10	Keratin, type I cytoskeletal 10; Keratins, type I (584 aa)
	KRT83	Keratin, type II cuticular Hb3; Keratins, type II (493 aa)
	RUNX1T1	Protein CBFA2T1; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal; Zinc fingers MYND-type (663 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRT1	KRT10	ENSP00000252244	ENSP00000269576	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 10; Keratins, type I	0.999
KRT1	KRT12	ENSP00000252244	ENSP00000251643	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 12; May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity); Keratins, type I	0.944
KRT1	KRT13	ENSP00000252244	ENSP00000246635	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 13; Keratins, type I	0.946
KRT1	KRT14	ENSP00000252244	ENSP00000167586	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	0.935
KRT1	KRT15	ENSP00000252244	ENSP00000254043	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 15; Keratins, type I	0.947
KRT1	KRT20	ENSP00000252244	ENSP00000167588	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity); Keratins, type I	0.921
KRT1	KRT23	ENSP00000252244	ENSP00000209718	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 23; Keratins, type I	0.911
KRT1	KRT24	ENSP00000252244	ENSP00000264651	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 24; Keratins, type I	0.940
KRT1	KRT31	ENSP00000252244	ENSP00000251645	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha1; Keratins, type I	0.915
KRT1	KRT32	ENSP00000252244	ENSP00000225899	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family	0.921
KRT1	KRT33A	ENSP00000252244	ENSP00000007735	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha3-I; Keratins, type I; Belongs to the intermediate filament family	0.908
KRT1	KRT33B	ENSP00000252244	ENSP00000251646	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha3-II; Keratins, type I; Belongs to the intermediate filament family	0.915
KRT1	KRT37	ENSP00000252244	ENSP00000225550	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha7; Keratins, type I; Belongs to the intermediate filament family	0.921
KRT1	KRT38	ENSP00000252244	ENSP00000246646	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha8; Keratins, type I; Belongs to the intermediate filament family	0.923
KRT1	KRT5	ENSP00000252244	ENSP00000252242	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 5; Keratins, type II	0.997
KRT1	KRT6B	ENSP00000252244	ENSP00000252252	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 6B; Keratins, type II; Belongs to the intermediate filament family	0.911
KRT1	KRT6C	ENSP00000252244	ENSP00000252250	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family	0.913
KRT1	KRT71	ENSP00000252244	ENSP00000267119	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle	0.901
KRT1	KRT75	ENSP00000252244	ENSP00000252245	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle	0.901
KRT1	KRT82	ENSP00000252244	ENSP00000257974	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cuticular Hb2; Keratins, type II	0.902

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