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  • 11.0 [archived version]
STRINGSTRING
KRT1 KRT1 PRPH PRPH KRT74 KRT74 KRT71 KRT71 KRT85 KRT85 KRT82 KRT82 KRT79 KRT79 KRT5 KRT5 KRT84 KRT84 KRT24 KRT24 KRT3 KRT3 KRT83 KRT83 KRT72 KRT72 KRT20 KRT20 KRT6C KRT6C C9orf16 C9orf16 KRT76 KRT76 KRT6B KRT6B KRT78 KRT78 KRT80 KRT80 KRT73 KRT73 MIB1 MIB1 KRT7 KRT7 MIB2 MIB2 KRT75 KRT75 DES DES
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRT20Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity); Keratins, type I (424 aa)
KRT5Keratin, type II cytoskeletal 5; Keratins, type II (590 aa)
KRT1Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II (644 aa)
KRT75Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (551 aa)
KRT6CKeratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family (564 aa)
KRT6BKeratin, type II cytoskeletal 6B; Keratins, type II; Belongs to the intermediate filament family (564 aa)
PRPHPeripherin; Class-III neuronal intermediate filament protein (470 aa)
KRT85Keratin, type II cuticular Hb5; Keratins, type II (507 aa)
KRT84Keratin, type II cuticular Hb4; Keratins, type II (600 aa)
KRT82Keratin, type II cuticular Hb2; Keratins, type II (513 aa)
MIB1E3 ubiquitin-protein ligase MIB1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits [...] (1006 aa)
KRT24Keratin, type I cytoskeletal 24; Keratins, type I (525 aa)
KRT71Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (523 aa)
KRT83Keratin, type II cuticular Hb3; Keratins, type II (493 aa)
KRT72Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) (511 aa)
KRT78Keratin, type II cytoskeletal 78; Keratins, type II (520 aa)
KRT73Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) (540 aa)
KRT74Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable); Keratins, type II (529 aa)
KRT79Keratin, type II cytoskeletal 79; Keratins, type II; Belongs to the intermediate filament family (535 aa)
KRT7Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7); Keratins, type II (469 aa)
KRT76Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification; Keratins, type II (638 aa)
C9orf16UPF0184 protein C9orf16; Chromosome 9 open reading frame 16 (83 aa)
DESDesmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] (470 aa)
KRT80Keratin, type II cytoskeletal 80; Keratins, type II (452 aa)
KRT3Keratin, type II cytoskeletal 3; Keratins, type II (628 aa)
MIB2E3 ubiquitin-protein ligase MIB2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors; Ankyrin repeat domain containing (1070 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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