• Version:
  • 11.0 [archived version]
STRINGSTRING
KRT7 KRT7 KRT79 KRT79 KRT9 KRT9 KRT31 KRT31 KRT3 KRT3 KRT20 KRT20 KRT32 KRT32 KRT6A KRT6A KRT13 KRT13 KRT6C KRT6C KRT12 KRT12 KRT76 KRT76 KRT14 KRT14 KRT37 KRT37 KRT8 KRT8 KRT33B KRT33B KRT38 KRT38 KRT4 KRT4 KRT6B KRT6B KRT33A KRT33A KRT5 KRT5 KRT23 KRT23 ABI2 ABI2 DCTN2 DCTN2 GRB2 GRB2 EPS15 EPS15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRT33AKeratin, type I cuticular Ha3-I; Keratins, type I; Belongs to the intermediate filament family (404 aa)
KRT14Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro (472 aa)
KRT20Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity); Keratins, type I (424 aa)
KRT23Keratin, type I cytoskeletal 23; Keratins, type I (422 aa)
KRT37Keratin, type I cuticular Ha7; Keratins, type I; Belongs to the intermediate filament family (449 aa)
KRT32Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family (448 aa)
KRT13Keratin, type I cytoskeletal 13; Keratins, type I (458 aa)
KRT38Keratin, type I cuticular Ha8; Keratins, type I; Belongs to the intermediate filament family (456 aa)
KRT9Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly; Belongs to the intermediate filament family (623 aa)
KRT12Keratin, type I cytoskeletal 12; May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity); Keratins, type I (494 aa)
KRT31Keratin, type I cuticular Ha1; Keratins, type I (416 aa)
KRT33BKeratin, type I cuticular Ha3-II; Keratins, type I; Belongs to the intermediate filament family (404 aa)
KRT5Keratin, type II cytoskeletal 5; Keratins, type II (590 aa)
KRT6CKeratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family (564 aa)
KRT6BKeratin, type II cytoskeletal 6B; Keratins, type II; Belongs to the intermediate filament family (564 aa)
ABI2Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity) (513 aa)
KRT79Keratin, type II cytoskeletal 79; Keratins, type II; Belongs to the intermediate filament family (535 aa)
KRT7Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7); Keratins, type II (469 aa)
KRT76Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification; Keratins, type II (638 aa)
EPS15Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internali [...] (896 aa)
KRT6AKeratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair; Belongs to the intermediate filament family (564 aa)
GRB2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing (217 aa)
DCTN2Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin (406 aa)
KRT3Keratin, type II cytoskeletal 3; Keratins, type II (628 aa)
KRT4Keratin, type II cytoskeletal 4; Keratins, type II; Belongs to the intermediate filament family (520 aa)
KRT8Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Keratins, type II (511 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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