26 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	RPL18A	Ribosomal protein L18a (176 aa)
	SEC61B	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum; Belongs to the SEC61-beta family (96 aa)
	RPL19	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family (196 aa)
	RCVRN	Recoverin; Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse; EF-hand domain containing (200 aa)
	GUCA1B	Guanylyl cyclase-activating protein 2; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing (200 aa)
	RPL35	60S ribosomal protein L35; Component of the large ribosomal subunit (123 aa)
	GUCA1C	Guanylyl cyclase-activating protein 3; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)- sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing (209 aa)
	EFCAB1	EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1 (211 aa)
	SEMA3A	Semaphorin-3A; Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1; Immunoglobulin like domain containing (771 aa)
	KCNIP3	Calsenilin; Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity); EF-hand domain containing (256 aa)
	USP32	Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family (1604 aa)
	KCND3	Potassium voltage-gated channel subfamily D member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits; Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily (655 aa)
	NCS1	Neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity); Belongs to the recoverin family (190 aa)
	HPCAL4	Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; EF-hand domain containing (191 aa)
	HPCA	Neuron-specific calcium-binding protein hippocalcin; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide- mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity); Belongs to the recoverin family (193 aa)
	SRC	Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy be [...] (536 aa)
	KCNIP4	Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family (250 aa)
	DPP10	Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family (800 aa)
	GUCA1A	Guanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing (201 aa)
	NCALD	Neurocalcin-delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions; EF-hand domain containing (193 aa)
	VSNL1	Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family (191 aa)
	KCNIP1	Potassium voltage-gated channel interacting protein 1; EF-hand domain containing (241 aa)
	KCNIP2	Kv channel-interacting protein 2; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity); EF-hand domain containing (285 aa)
	FAU	Ubiquitin-like protein FUBI; FAU, ubiquitin like and ribosomal protein S30 fusion (133 aa)
	ENSG00000270800	RPS10-NUDT3 readthrough (286 aa)
	HPCAL1	Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family (193 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DPP10	KCND3	ENSP00000376855	ENSP00000319591	Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	Potassium voltage-gated channel subfamily D member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits; Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily	0.795
DPP10	KCNIP1	ENSP00000376855	ENSP00000414886	Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	Potassium voltage-gated channel interacting protein 1; EF-hand domain containing	0.700
DPP10	KCNIP2	ENSP00000376855	ENSP00000420040	Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	Kv channel-interacting protein 2; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity); EF-hand domain containing	0.644
DPP10	KCNIP3	ENSP00000376855	ENSP00000295225	Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	Calsenilin; Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity); EF-hand domain containing	0.677
DPP10	KCNIP4	ENSP00000376855	ENSP00000371587	Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family	0.604
ENSG00000270800	FAU	ENSP00000475027	ENSP00000435370	RPS10-NUDT3 readthrough	Ubiquitin-like protein FUBI; FAU, ubiquitin like and ribosomal protein S30 fusion	0.979
ENSG00000270800	KCND3	ENSP00000475027	ENSP00000319591	RPS10-NUDT3 readthrough	Potassium voltage-gated channel subfamily D member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits; Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily	0.661
ENSG00000270800	RPL18A	ENSP00000475027	ENSP00000222247	RPS10-NUDT3 readthrough	Ribosomal protein L18a	0.969
ENSG00000270800	RPL19	ENSP00000475027	ENSP00000225430	RPS10-NUDT3 readthrough	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family	0.976
ENSG00000270800	RPL35	ENSP00000475027	ENSP00000259469	RPS10-NUDT3 readthrough	60S ribosomal protein L35; Component of the large ribosomal subunit	0.966
ENSG00000270800	SEC61B	ENSP00000475027	ENSP00000223641	RPS10-NUDT3 readthrough	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum; Belongs to the SEC61-beta family	0.964
FAU	ENSG00000270800	ENSP00000435370	ENSP00000475027	Ubiquitin-like protein FUBI; FAU, ubiquitin like and ribosomal protein S30 fusion	RPS10-NUDT3 readthrough	0.979
FAU	KCND3	ENSP00000435370	ENSP00000319591	Ubiquitin-like protein FUBI; FAU, ubiquitin like and ribosomal protein S30 fusion	Potassium voltage-gated channel subfamily D member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits; Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily	0.788
FAU	RPL18A	ENSP00000435370	ENSP00000222247	Ubiquitin-like protein FUBI; FAU, ubiquitin like and ribosomal protein S30 fusion	Ribosomal protein L18a	0.999
FAU	RPL19	ENSP00000435370	ENSP00000225430	Ubiquitin-like protein FUBI; FAU, ubiquitin like and ribosomal protein S30 fusion	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family	0.999
FAU	RPL35	ENSP00000435370	ENSP00000259469	Ubiquitin-like protein FUBI; FAU, ubiquitin like and ribosomal protein S30 fusion	60S ribosomal protein L35; Component of the large ribosomal subunit	0.999
FAU	SEC61B	ENSP00000435370	ENSP00000223641	Ubiquitin-like protein FUBI; FAU, ubiquitin like and ribosomal protein S30 fusion	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum; Belongs to the SEC61-beta family	0.956
GUCA1A	GUCA1B	ENSP00000377784	ENSP00000230361	Guanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing	Guanylyl cyclase-activating protein 2; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing	0.920
GUCA1A	GUCA1C	ENSP00000377784	ENSP00000261047	Guanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing	Guanylyl cyclase-activating protein 3; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)- sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing	0.906
GUCA1B	GUCA1A	ENSP00000230361	ENSP00000377784	Guanylyl cyclase-activating protein 2; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing	Guanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing	0.920

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